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Senescence and senolysis in cancer: The latest findings
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Senescence and senolysis in cancer: The latest findings
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Journal Article
Senescence and senolysis in cancer: The latest findings
2024
Overview
Aging is a life phenomenon that occurs in most living organisms and is a major risk factor for many diseases, including cancer. Cellular senescence is a cellular trait induced by various genomic and epigenetic stresses. Senescent cells are characterized by irreversible cell growth arrest and excessive secretion of inflammatory cytokines (senescence‐associated secretory phenotypes, SASP). Chronic tissue microinflammation induced by SASP contributes to the pathogenesis of a variety of age‐related diseases, including cancer. Senolysis is a promising new strategy to selectively eliminate senescent cells in order to suppress chronic inflammation, suggesting its potential use as an anticancer therapy. This review summarizes recent findings on the molecular basis of senescence in cancer cells and senolysis. Characteristics of “cellular senescence” and “aging”. Cellular senescence is one of the molecular mechanisms underlying aging. Cellular senescence is characterized by irreversible cell growth arrest and excessive secretion of senescence‐associated secretory phenotypes (SASP).
