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Viruses transfer the antiviral second messenger cGAMP between cells

by Bridgeman, A. , Borrow, P. , Rehwinkel, J. , Dong, T. , Davenne, T. , Kaever, V. , Partridge, T. , Maelfait, J. , Mayer, A. , Peng, Y.

in AIDS Vaccines - immunology / Cellular biology / Dendritic Cells - immunology / Dendritic Cells - virology / Deoxyribonucleic acid / DNA / Genes / Genes, Reporter / Genetic Vectors - genetics / Genetic Vectors - metabolism / HEK293 Cells / Herpes Simplex - immunology / Herpes Simplex - prevention & control / Herpes Simplex Virus Vaccines - immunology / Herpesvirus / Herpesvirus 1, Human - genetics / Herpesvirus 1, Human - metabolism / HIV Infections - immunology / HIV Infections - metabolism / HIV Infections - prevention & control / HIV-1 - genetics / HIV-1 - metabolism / Humans / Immune response / Immune systems / Immunity, Innate - genetics / Immunity, Innate - immunology / Interferon-beta - genetics / Interferon-beta - immunology / Lentivirus / Mathematical analysis / Nucleic acids / Nucleotides, Cyclic - metabolism / Promoter Regions, Genetic / Second Messenger Systems / Signal transduction / Stimulators / Transcriptional Activation / Vaccines / Vectors (mathematics) / Viral infections / Virion - genetics / Virion - metabolism / Virology / Viruses

2015

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Viruses transfer the antiviral second messenger cGAMP between cells

by Bridgeman, A. , Borrow, P. , Rehwinkel, J. , Dong, T. , Davenne, T. , Kaever, V. , Partridge, T. , Maelfait, J. , Mayer, A. , Peng, Y.

2015

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Viruses transfer the antiviral second messenger cGAMP between cells

by Bridgeman, A. , Borrow, P. , Rehwinkel, J. , Dong, T. , Davenne, T. , Kaever, V. , Partridge, T. , Maelfait, J. , Mayer, A. , Peng, Y.

2015

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Journal Article

Viruses transfer the antiviral second messenger cGAMP between cells

Bridgeman, A.,

Borrow, P.,

Rehwinkel, J.,

Dong, T.,

Davenne, T.,

Kaever, V.,

Partridge, T.,

Maelfait, J.,

Mayer, A.,

Peng, Y.

2015

Overview

Cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA during virus infection and induces an antiviral state. cGAS signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING). We show that cGAMP is incorporated into viral particles, including lentivirus and herpesvirus virions, when these are produced in cGAS-expressing cells. Virions transferred cGAMP to newly infected cells and triggered a STING-dependent antiviral program.These effects were independent of exosomes and viral nucleic acids. Our results reveal a way by which a signal for innate immunity is transferred between cells, potentially accelerating and broadening antiviral responses. Moreover, infection of dendritic cells with cGAMP-loaded lentiviruses enhanced their activation. Loading viral vectors with cGAMP therefore holds promise for vaccine development.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

AIDS Vaccines - immunology

/ Cellular biology

/ Dendritic Cells - immunology

/ Dendritic Cells - virology

/ Deoxyribonucleic acid

/ DNA

/ Genes