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Light-induced modulation of the mitochondrial respiratory chain activity: possibilities and limitations
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Light-induced modulation of the mitochondrial respiratory chain activity: possibilities and limitations
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Journal Article
Light-induced modulation of the mitochondrial respiratory chain activity: possibilities and limitations
2020
Overview
Biological effects of high fluence low-power (HFLP) lasers have been reported for some time, yet the molecular mechanisms procuring cellular responses remain obscure. A better understanding of the effects of HFLP lasers on living cells will be instrumental for the development of new experimental and therapeutic strategies. Therefore, we investigated sub-cellular mechanisms involved in the laser interaction with human hepatic cell lines. We show that mitochondria serve as sub-cellular “sensor” and “effector” of laser light non-specific interactions with cells. We demonstrated that despite blue and red laser irradiation results in similar apoptotic death, cellular signaling and kinetic of biochemical responses are distinct. Based on our data, we concluded that blue laser irradiation inhibited cytochrome c oxidase activity in electron transport chain of mitochondria. Contrary, red laser triggered cytochrome c oxidase excessive activation. Moreover, we showed that Bcl-2 protein inhibited laser-induced toxicity by stabilizing mitochondria membrane potential. Thus, cells that either overexpress or have elevated levels of Bcl-2 are protected from laser-induced cytotoxicity. Our findings reveal the mechanism how HFLP laser irradiation interfere with cell homeostasis and underscore that such laser irradiation permits remote control of mitochondrial function in the absence of chemical or biological agents.
Publisher
Springer International Publishing,Springer Nature B.V
Subject
/ Apoptosis - radiation effects
/ Biomedical and Life Sciences
/ Cell Survival - radiation effects
/ Electron Transport - genetics
/ Electron Transport - radiation effects
/ Electron Transport Complex IV - genetics
/ Fluence
/ Gene Expression Regulation - radiation effects
/ Humans
/ Lasers
/ Membrane Potential, Mitochondrial - genetics
/ Membrane Potential, Mitochondrial - radiation effects
/ Mitochondria - radiation effects
/ Mitochondrial Membranes - metabolism
/ Mitochondrial Membranes - radiation effects
/ Original
/ Oxidase
/ Oxidation-Reduction - radiation effects
/ Reactive Oxygen Species - metabolism
/ Toxicity
