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Journal Article
Metabolism as a guiding force for immunity
2019
Overview
Recent studies indicate that cellular metabolism plays a key role in supporting immune cell maintenance and development. Here, we review how metabolism guides immune cell activation and differentiation to distinct cellular states, and how differential regulation of metabolism allows for context-dependent support during activation and lineage commitment. We discuss emerging principles of metabolic support of immune cell function in physiology and disease, as well as their general relevance to the field of cell biology.
In this Review, Horng and colleagues cover the emerging roles of cellular metabolism in guiding immune cell activation and cell fate decisions, and discuss how differential metabolic regulation allows for context specificity.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/1
/ 13/106
/ 13/21
/ 13/31
/ 13/95
/ 38
/ 38/1
/ 631/250
/ 64
/ 64/60
/ 96
/ 96/31
/ Animals
/ Biomedical and Life Sciences
/ Cell Differentiation - immunology
/ Cell Differentiation - physiology
/ Energy Metabolism - immunology
/ Energy Metabolism - physiology
/ Humans
/ Immunity
/ T cells
