Journal Article

Characteristics of radiofrequency lesions in patients with symptomatic periesophageal vagal nerve injury after pulmonary vein isolation

Yoshimura, Shingo, Sasaki, Takehito, Naito, Shigeto, Aoki, Hideyuki, Kaseno, Kenichi, Matsuo, Yuji, Goto, Koji, Miki, Yuko, Nakamura, Kohki, Take, Yutaka

2024

Overview

Background Periesophageal vagal nerve injury (PNI) is an unpredictable and serious complication of atrial fibrillation (AF) ablation. We aimed to identify the factors associated with symptomatic PNI. Methods This study included 1391 patients who underwent ablation index‐guided pulmonary vein isolation (PVI) using the CARTO system. The target ablation index was set at 550, except for the left atrial (LA) posterior wall near the esophagus, where radiofrequency (RF) power and duration were limited. Ten patients (0.72%) were diagnosed with symptomatic PNI. We randomly selected 40 patients without PNI (1:4 ratio) matched based on age, sex, body mass index, LA diameter, type of AF, and esophageal location. We measured the shortest distance from the RF lesions to the esophagus (LED) and classified the RF lesions according to the LED into four groups: 0–5, 5–10, 10–15, and 15–20 mm. We conducted a comparative analysis of classified RF lesions between patients with PNI (n = 10) and those without (n = 40). Results The contact force at LED 0–5 mm was significantly higher in patients with PNI than in those without (14.6 ± 1.7 vs. 12.0 ± 2.9 g; p = .01). Multivariate logistic analysis revealed that the independent factor for PNI was contact force at an LED of 0–5 mm (odds ratio: 1.506; 95% confidence interval: 1.053–2.153; p = .025). Conclusions The symptomatic PNI was significantly associated with a higher contact force near the esophagus. Strategies for regulating contact force near the esophagus may aid in the prevention of PNI. Periesophageal vagal nerve injury (PNI) is an unpredictable complication of atrial fibrillation ablation. We measured the distance from radiofrequency lesions to the esophagus (LED) and assessed RF lesions in patients with symptomatic PNI. PNI was significantly associated with a higher contact force at an LED of 0–5 mm.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
• Subject: Ablation / atrial fibrillation / Body mass index / Cardiac arrhythmia / catheter ablation / Catheters / Endoscopy / Esophagus / Lesions / Original / periesophageal vagal nerve injury / pulmonary vein isolation / Radio frequency / radiofrequency lesions / Regression analysis / Veins & arteries