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Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody

by Song, Jia-Cui , Zhou, Nian-Yu , He, Xian , Wu, Qin , Tang, Dan-Li , Yin, Zhao-Fang , Li, Hui-Ping , Li, Nan , Chen, Tao , Chen, Shan-Shan , Weng, Dong , Qiu, Hui , Zhao, Meng-Meng , Lu, Li-Qin

in Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) / Antigens / Chromatography / Drug dosages / Hospitals / humanized surfactant protein-A (hSP-A) / humanized surfactant protein-A nanobody (SPANb) / Medicine / Proteins / Pulmonary fibrosis / Severe acute respiratory syndrome / Surfactants

2021

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Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody

by Song, Jia-Cui , Zhou, Nian-Yu , He, Xian , Wu, Qin , Tang, Dan-Li , Yin, Zhao-Fang , Li, Hui-Ping , Li, Nan , Chen, Tao , Chen, Shan-Shan , Weng, Dong , Qiu, Hui , Zhao, Meng-Meng , Lu, Li-Qin

2021

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Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody

by Song, Jia-Cui , Zhou, Nian-Yu , He, Xian , Wu, Qin , Tang, Dan-Li , Yin, Zhao-Fang , Li, Hui-Ping , Li, Nan , Chen, Tao , Chen, Shan-Shan , Weng, Dong , Qiu, Hui , Zhao, Meng-Meng , Lu, Li-Qin

2021

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Journal Article

Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody

Song, Jia-Cui,

Zhou, Nian-Yu,

He, Xian,

Wu, Qin,

Tang, Dan-Li,

Yin, Zhao-Fang,

Li, Hui-Ping,

Li, Nan,

Chen, Tao,

Chen, Shan-Shan,

Weng, Dong,

Qiu, Hui,

Zhao, Meng-Meng,

Lu, Li-Qin

2021

Overview

Glucocorticoid (GC) hormone has been commonly used to treat systemic inflammation and immune disorders. However, the side effects associated with long-term use of high-dose GC hormone limit its clinical application seriously. GC hormone that can specifically target the lung might decrease the effective dosage and thus reduce GC-associated side effects. In this study, we successfully prepared human lung-targeting liposomal methylprednisolone crosslinked with nanobody (MPS-NSSLs-SPANb). Our findings indicate that MPS-NSSLs-SPANb may reduce the effective therapeutic dosage of MPS, achieve better efficacy, and reduce GC-associated side effects. In addition, MPS-NSSLs-SPANb showed higher efficacy and lower toxicity than conventional MPS.

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Publisher

Taylor & Francis,Taylor & Francis Ltd,Taylor & Francis Group

Subject

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF)

/ humanized surfactant protein-A (hSP-A)

/ humanized surfactant protein-A nanobody (SPANb)