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Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator
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Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator
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Journal Article
Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator
2017
Overview
Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized β-actin filament assembly at the site of cytokinesis. β-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of β-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions.
Cytokinesis is initiated by the localized assembly of the contractile ring. Here the authors show that the stabilization and organization of the cytokinetic furrow requires localized β-actin filament assembly at the site of cytokinesis by an actin isoform specific nucleator.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Actin
/ Actin Cytoskeleton - metabolism
/ Adaptor Proteins, Signal Transducing - metabolism
/ Assembly
/ Blood Platelets - physiology
/ Formins
/ Furrows
/ Humanities and Social Sciences
/ Humans
/ Microfilament Proteins - genetics
/ Microfilament Proteins - metabolism
/ Plasma
/ Protein Isoforms - metabolism
/ Proteins
/ Recombinant Proteins - metabolism
/ rhoA GTP-Binding Protein - metabolism
/ RNA, Small Interfering - metabolism
/ Science
