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Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

by Spence, Brittany , Heath, Bradette , Powers, Olivia C , Ansel, Jessica L , Tolboom Jeroen T B M , Porto Maciel , Tostanoski, Lisa H , Yu Jingyou , Chang Aiquan , Holman Shaikim , Sadoff Jerald , Chandrashekar Abishek , Jacob-Dolan, Catherine , Cox, Freek , Le Gars Mathieu , Barouch, Dan H , de Groot Anne Marit , Schuitemaker Hanneke , Stephenson, Kathryn E , Barrett, Julia , Sanborn, Owen , Lewis, Mark G , Heerwegh Dirk , Zahn, Roland C , Andersen, Hanne , Kar Swagata , Lok, Megan , Patel, Shivani , Gardner, Sarah , Wegmann, Frank , Nase, Danielle , Seaman, Michael S , Cayer, Kathleen , Jaegle Kate , Sellers, Daniel

in Antibodies / COVID-19 / COVID-19 vaccines / Immunization / Rodents / Severe acute respiratory syndrome coronavirus 2

2022

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Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

in Antibodies / COVID-19 / COVID-19 vaccines / Immunization / Rodents / Severe acute respiratory syndrome coronavirus 2

2022

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Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

in Antibodies / COVID-19 / COVID-19 vaccines / Immunization / Rodents / Severe acute respiratory syndrome coronavirus 2

2022

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Journal Article

Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

Spence, Brittany,

Heath, Bradette,

Powers, Olivia C,

Ansel, Jessica L,

Tolboom Jeroen T B M,

Porto Maciel,

Tostanoski, Lisa H,

Yu Jingyou,

Chang Aiquan,

Holman Shaikim,

Sadoff Jerald,

Chandrashekar Abishek,

Jacob-Dolan, Catherine,

Cox, Freek,

Le Gars Mathieu,

Barouch, Dan H,

de Groot Anne Marit,

Schuitemaker Hanneke,

Stephenson, Kathryn E,

Barrett, Julia,

Sanborn, Owen,

Lewis, Mark G,

Heerwegh Dirk,

Zahn, Roland C,

Andersen, Hanne,

Kar Swagata,

Lok, Megan,

Patel, Shivani,

Gardner, Sarah,

Wegmann, Frank,

Nase, Danielle,

Seaman, Michael S,

Cayer, Kathleen,

Jaegle Kate,

Sellers, Daniel

2022

Overview

SARS-CoV-2 Spike-specific binding and neutralizing antibodies, elicited either by natural infection or vaccination, have emerged as potential correlates of protection. An important question, however, is whether vaccine-elicited antibodies in humans provide direct, functional protection from SARS-CoV-2 infection and disease. In this study, we explored directly the protective efficacy of human antibodies elicited by Ad26.COV2.S vaccination by adoptive transfer studies. IgG from plasma of Ad26.COV2.S vaccinated individuals was purified and transferred into naïve golden Syrian hamster recipients, followed by intra-nasal challenge of the hamsters with SARS-CoV-2. IgG purified from Ad26.COV2.S-vaccinated individuals provided dose-dependent protection in the recipient hamsters from weight loss following challenge. In contrast, IgG purified from placebo recipients provided no protection in this adoptive transfer model. Attenuation of weight loss correlated with binding and neutralizing antibody titers of the passively transferred IgG. This study suggests that Ad26.COV2.S-elicited antibodies in humans are mechanistically involved in protection against SARS-CoV-2.

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Publisher

Nature Publishing Group

Subject

/ Rodents

/ Severe acute respiratory syndrome coronavirus 2