Journal Article

Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers

Hartman, Mikael, Iau, Philip Tsau Choong, Tan, Benita Kiat Tee, Tan, Ern Yu, Tan, Veronique Kiak Mien, Lu, Sarah Qinghui, Seah, Jaime Chin Mui, Lee, Soo Chin, Lee, Wai Peng, Lim, Swee Ho, Woo, Evan, Chia, Kee Seng, Lee, Jin Yee, Chen, Juliana Jia Chuan, Wong, Fuh Yong, Yan, Zhiyan, van Dam, Rob Martinus, Putti, Thomas, Madhukumar, Preetha, Tan, Su Ming, Yong, Wei Sean, Mok, Chi Wei, Buhari, Shaik Ahmad, Ho, Peh Joo, Miao, Hui, Chan, Patrick Mun Yew, Li, Jingmei, Sim, Xueling, Dent, Rebecca, Yeoh, Yen Shing, Chan, Ching Wan, Lim, Geok Hoon

2021

Overview

This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Breast cancer / Demographic aspects / Genetic aspects / Medicine and Health Sciences / People and Places / Prognosis