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Journal Article
tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis
2024
Overview
Investigating ligand-protein complexes is essential in the areas of chemical biology and drug discovery. However, detailed information on key reagents such as fluorescent tracers and associated data for the development of widely used bioluminescence resonance energy transfer (BRET) assays including NanoBRET, time-resolved Förster resonance energy transfer (TR-FRET) and fluorescence polarization (FP) assays are not easily accessible to the research community. We created tracerDB, a curated database of validated tracers. This resource provides an open access knowledge base and a unified system for tracer and assay validation. The database is freely available at
https://www.tracerdb.org/
.
Tracers are fluorescent protein ligands required for various displacement assays. Here, the authors announce a curated database named tracerDB, which will make essential tracer data, contributed by the worldwide research community, easily available and searchable.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Assaying
/ Bioluminescence Resonance Energy Transfer Techniques - methods
/ Fluorescence Polarization - methods
/ Fluorescence resonance energy transfer
/ Fluorescence Resonance Energy Transfer - methods
/ Fluorescent Dyes - chemistry
/ Humanities and Social Sciences
/ Humans
/ Kinases
/ Knowledge bases (artificial intelligence)
/ Ligands
/ Proteins
/ R&D
/ Reagents
/ Science
/ Tracers
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