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The Antioxidant Effects of L-carnitine on D-galactose Induced Aging Mice
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The Antioxidant Effects of L-carnitine on D-galactose Induced Aging Mice
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Journal Article
The Antioxidant Effects of L-carnitine on D-galactose Induced Aging Mice
2012
Overview
[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0.25, 0.5 and 1.0 g/（kg d）, a total of 5 groups. Using the subacute D-galactose induced aging models, the mice were killed after 6 weeks of experiment and the activity of Superoxide dismutase （SOD）, Glutathione peroxidase （GSH-Px） and Malondialdehyde （MDA） content in plasma, brain and liver tissue were determined. [ Result.] The activity of SOD and GSH-Px in plasma, brain and liver tissue were significantly increased after treated with LC, while the content of MDA were decreased with a dose-dependent manner. [ Conclusion] LC had anti-aging effects in mice, and the mechanism may be correlated with the antioxidation.
