Journal Article

Tumor Burden Score and Serum Alpha-fetoprotein Subclassify Intermediate-Stage Hepatocellular Carcinoma

Endo, Yutaka, Guglielmi, Alfredo, Lam, Vincent, Munir, Muhammad Musaab, Pawlik, Timothy M, Marques, Hugo P, Popescu, Irinel, Endo, Itaru, Alaimo, Laura, Cauchy, François, Hugh, Tom, Poultsides, George A, Shen, Feng, Moazzam, Zorays, Shaikh, Chanza, Lima, Henrique A, Kitago, Minoru, Alexandrescu, Sorin, Martel, Guillaume, Resende, Vivian

2022

Overview

Background Resection of Barcelona Clinic Liver Cancer (BCLC) intermediate-stage hepatocellular carcinoma (HCC) remains controversial. While not recommended by the BCLC algorithm, some patients may indeed benefit from hepatectomy. We sought to identify that subset of patients who might derive long-term survival benefit from resection. Methods Intermediate-stage HCC patients who underwent curative-intent resection were identified from an international multi-institutional database. Factors associated with long-term prognosis were identified using multivariate analysis and a risk score was developed and assessed. Results Among 194 patients, most individuals had two tumors ( n  = 123, 63.4%) with a median size of 6.0 cm (IQR, 4.0–8.4) for a median tumor burden score (TBS) of 6.5 (IQR, 5.0–9.1); median alpha-fetoprotein (AFP) was 23.9 ng/mL (IQR, 5.0–503.2), and median overall survival (OS) was 69 months (IAR, 60.7–77.3). Factors associated with OS included AFP (referent ≤ 20 ng/mL, > 20 ng/mL: HR 1.78 95%CI, 1.09–2.89) and TBS (referent TBS ≤ 8.0, TBS > 8.0: HR 1.72 95%CI, 1.07–2.75). While 71 (36.6%) patients had neither risk factor, 79 (40.7%) and 44 (22.7%) had 1 or 2, respectively. A simplified score stratified patients relative to recurrence-free survival (RFS) (0: 33.6% vs. 1: 18.0% vs. 2: 14.7%) (AUC 0.60) and recurrence time (i.e., < 6 months after surgery) (0: 21.3% vs. 1: 43.1% vs. 2: 68.6%) (AUC 0.69) (both p  < 0.001). Of note, a higher score was also associated with incrementally worse 5-year OS (0: 68.1% vs. 1: 61.0% vs. 2: 29.9%) (AUC 0.62) ( p  < 0.001). Conclusion Long-term OS and RFS outcomes varied considerably. Using a simple risk score, patients with low AFP and low TBS were identified as the subset of individuals most likely to benefit from resection.

• Publisher: Elsevier BV,Springer US,Springer Nature B.V
• Subject: Alpha-fetoprotein / alpha-Fetoproteins / alpha-Fetoproteins - analysis / BCLC B / Carcinoma, Hepatocellular / Carcinoma, Hepatocellular - pathology / Gastroenterology / Gastrointestinal surgery / HCC CIR / Hepatectomy / Hepatitis / Hospitals / Humans / Intermediate-stage hepatocellular carcinoma / Liver cancer / Liver Neoplasms / Liver Neoplasms - pathology / Medical prognosis / Medicine / Medicine & Public Health / Multi-institutional database / Neoplasm Staging / Original Article / Prognosis / Retrospective Studies / Surgery / Tumor Burden / Tumor burden score / Tumors