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Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Behavioral Indices of Methamphetamine in Rats
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Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Behavioral Indices of Methamphetamine in Rats
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Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Behavioral Indices of Methamphetamine in Rats
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Journal Article
Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Behavioral Indices of Methamphetamine in Rats
2015
Overview
Background:Methamphetamine is a major drug of abuse with no effective pharmacotherapy available. Trace amine associated receptor 1 is implicated in cocaine addiction and represents a potential therapeutic target. However, the effects of trace amine associated receptor 1 agonists on addiction-related behavioral effects of methamphetamine are unknown.Methods:This study examined the effects of a trace amine associated receptor 1 agonist RO5263397 on methamphetamine-induced behavioral sensitization, methamphetamine self-administration, cue- and methamphetamine-induced reinstatement of drug seeking, and cue-induced reinstatement of sucrose-seeking behaviors in rats. Male Sprague-Dawley rats were used to examine the effects of methamphetamine alone and in combination with the trace amine associated receptor 1 agonist RO5263397 (3.2–10mg/kg).Results:RO5263397 dose-dependently attenuated the expression of behavioral sensitization to methamphetamine, reduced methamphetamine self-administration, and decreased both cue- and a priming dose of methamphetamine-induced reinstatement of drug-seeking behaviors. However, RO5263397 did not alter cue-induced reinstatement of sucrose-seeking behavior.Conclusions:Taken together, trace amine associated receptor 1 agonists attenuate some abuse-related behavioral effects of methamphetamine, strongly suggesting that drugs activating trace amine associated receptor 1 may be potentially useful for the treatment of methamphetamine addiction and warrant further studies.
Publisher
Oxford University Press
Subject
/ Akathisia, Drug-Induced - drug therapy
/ Akathisia, Drug-Induced - physiopathology
/ Amphetamine-Related Disorders - drug therapy
/ Amphetamine-Related Disorders - physiopathology
/ Animals
/ Behavior
/ Behavior, Addictive - drug therapy
/ Behavior, Addictive - physiopathology
/ Central Nervous System Stimulants - administration & dosage
/ Cues
/ Dietary Sucrose - administration & dosage
/ Dose-Response Relationship, Drug
/ Drug-Seeking Behavior - drug effects
/ Drug-Seeking Behavior - physiology
/ Male
/ Methamphetamine - administration & dosage
/ Receptors, G-Protein-Coupled - agonists
