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Journal Article
Assessing congestion using estimated plasma volume status: Ready for prime time?
2025
Overview
Multiple linear regression analysis showed a significantly greater increase in LVEF and decrease in LV volume index over time in the low-ePVS group. [...]the higher rates of all-cause mortality, cardiovascular mortality and HFH observed in these patients could be attributable to known and unknown clinical factors beyond residual congestion, even after meticulously executed statistical adjustments. Given the dynamic nature of congestion, it is challenging to ascertain that the adverse impact of high ePVS on long-term outcomes is simply from intravascular congestion, especially without repeated ePVS measurements. [...]using only haemoglobin and haematocrit levels in the ePVS calculation might oversimplify congestion assessment. [...]although ePVS can be easily obtained and followed longitudinally,3 the effective strategy for managing patients with high ePVS is unknown.
