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Human GM-CSF Autoantibodies and Reproduction of Pulmonary Alveolar Proteinosis
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Human GM-CSF Autoantibodies and Reproduction of Pulmonary Alveolar Proteinosis
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Journal Article
Human GM-CSF Autoantibodies and Reproduction of Pulmonary Alveolar Proteinosis
2009
Overview
To the Editor:
Idiopathic pulmonary alveolar proteinosis is a rare disease in which surfactant lipids and proteins accumulate in pulmonary alveolar macrophages and alveoli, resulting in respiratory insufficiency and, in severe cases, respiratory failure.
1
Granulocyte–macrophage colony-stimulating factor (GM-CSF) autoantibodies occur in these patients
2
and may mediate the pathogenesis of this disease, but they are also present in healthy persons and in immune globulin prepared from plasma obtained from healthy persons. Since GM-CSF is required for surfactant catabolism by alveolar macrophages in mice, we hypothesized that high levels of GM-CSF autoantibodies (i.e., levels sufficient to eliminate endogenous GM-CSF priming of myeloid . . .
Publisher
Massachusetts Medical Society
Subject
/ Bars
/ Bronchoalveolar Lavage Fluid - chemistry
/ Granulocyte-Macrophage Colony-Stimulating Factor - immunology
/ Humans
/ Lungs
/ Proteins
/ Pulmonary Alveolar Proteinosis - immunology
/ Pulmonary Alveolar Proteinosis - pathology
/ Pulmonary Alveoli - immunology
/ Pulmonary Alveoli - pathology
