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Direct Evidence for Secondary Loss of Mitochondria in Entamoeba histolytica
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Direct Evidence for Secondary Loss of Mitochondria in Entamoeba histolytica
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Journal Article
Direct Evidence for Secondary Loss of Mitochondria in Entamoeba histolytica
1995
Overview
Archezoan protists are thought to represent lineages that diverged from other eukaryotes before acquisition of the mitochondrion and other organelles. The parasite Entamoeba histolytica was originally included in this group. Ribosomal RNA based phylogenies, however, place E. histolytica on a comparatively recent branch of the eukaryotic tree, implying that its ancestors had these structures. In this study, direct evidence for secondary loss of mitochondrial function was obtained by isolating two E. histolytica genes encoding proteins that in other eukaryotes are localized in the mitochondrion: the enzyme pyridine nucleotide transhydrogenase and the chaperonin cpn60. Phylogenetic analysis of the E. histolytica homolog of cpn60 confirmed that it is specifically related to the mitochondrial lineage. The data suggest that a mitochondrial relic may persist in this organism. Similar studies are needed in archezoan protists to ascertain which, if any, eukaryotic lineages primitively lack mitochondria.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences,National Academy of Sciences
Subject
/ Animals
/ Cattle
/ Entamoeba histolytica - classification
/ Entamoeba histolytica - genetics
/ Entamoeba histolytica - metabolism
/ Genes
/ Humans
/ NADP Transhydrogenases - chemistry
/ NADP Transhydrogenases - genetics
/ Proteins
/ Rhodospirillum rubrum - enzymology
