Journal Article

Causative Links between Protein Aggregation and Oxidative Stress: A Review

Martin, Davy, Béringue, Vincent, Stress génotoxiques et cancer ; Université Paris-Sud - Paris 11 (UP11)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), Lévy, Elise, El Banna, Nadine, Truchet, Sandrine, Heneman-Masurel, Amélie, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)) ; Institut National de la Recherche Agronomique (INRA), Huang, Meng-Er, Vernis, Laurence, Baïlle, Dorothée, Rezaei, Human

2019

Overview

Compelling evidence supports a tight link between oxidative stress and protein aggregation processes, which are noticeably involved in the development of proteinopathies, such as Alzheimer's disease, Parkinson's disease, and prion disease. The literature is tremendously rich in studies that establish a functional link between both processes, revealing that oxidative stress can be either causative, or consecutive, to protein aggregation. Because oxidative stress monitoring is highly challenging and may often lead to artefactual results, cutting-edge technical tools have been developed recently in the redox field, improving the ability to measure oxidative perturbations in biological systems. This review aims at providing an update of the previously known functional links between oxidative stress and protein aggregation, thereby revisiting the long-established relationship between both processes.

• Publisher: MDPI,CCSD,MDPI AG
• Subject: Aggregates / Alzheimer Disease - metabolism / Amino acids / Animals / Biochemistry, Molecular Biology / Cancer / Cellular Biology / Chemical bonds / Disease / Homeostasis / Humans / Life Sciences / Molecular biology / Molecular weight / Oxidation / Oxidative Stress / Parkinson Disease - metabolism / Peptides / Physiology / Prion Diseases - metabolism / Protein Aggregates / Protein Aggregation, Pathological - metabolism / Proteins / Proteins - metabolism / Review
• ISBN: 0004844111000