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The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs
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The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs
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Journal Article
The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs
2020
Overview
N
6
-methyladenosine (m
6
A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently closed RNA molecules characterized by universality, diversity, stability and conservatism of evolution. Accumulating evidence shows that both m
6
A modification and circRNAs participate in the pathogenesis of multiple diseases, such as cancers, neurological diseases, autoimmune diseases, and infertility. Recently, m
6
A modification has been identified for its enrichment and vital biological functions in regulating circRNAs. In this review, we summarize the role of m
6
A modification in the regulation and function of circRNAs. Moreover, we discuss the potential applications and possible future directions in the field.
