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Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes

by Kitagawa, Yuko , Nakano, Yutaka , Kuroda, Kohei , Mizuguchi, Hiroyuki , Adachi, Shungo , Kushige, Hiroko , Toda, Yukiko , Matsuura, Katsuhisa , Yagi, Hiroshi , Abe, Yuta , Inui, Jumpei , Hasegawa, Yasushi , Tanaka, Masayuki , Nishi, Kotaro , Tomi, Masatoshi , Takayama, Kazuo , Kitago, Minoru , Morisaku, Toshinori , Kojima, Hideaki , Masuda, Shinako , Hirukawa, Kazuya , Hori, Shutaro , Tsuchida, Tomonori

in Animals / Cell culture / Cell Differentiation / Cytochrome P450 / decellularization / extracellular matrix / Gene expression / Growth factors / Hepatectomy / Hepatocytes / Hogs / human iPSCs / Humans / Immunodeficiency / Induced Pluripotent Stem Cells / Laboratory animals / Liver / microminiature pig / organ-derived scaffold / Pluripotency / Regenerative Medicine / Stem cell transplantation / Stem cells / Swine / Vascularization / Veins & arteries / xeno-implantation

2022

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Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes

2022

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Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes

2022

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Journal Article

Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes

Kitagawa, Yuko,

Nakano, Yutaka,

Kuroda, Kohei,

Mizuguchi, Hiroyuki,

Adachi, Shungo,

Kushige, Hiroko,

Toda, Yukiko,

Matsuura, Katsuhisa,

Yagi, Hiroshi,

Abe, Yuta,

Inui, Jumpei,

Hasegawa, Yasushi,

Tanaka, Masayuki,

Nishi, Kotaro,

Tomi, Masatoshi,

Takayama, Kazuo,

Kitago, Minoru,

Morisaku, Toshinori,

Kojima, Hideaki,

Masuda, Shinako,

Hirukawa, Kazuya,

Hori, Shutaro,

Tsuchida, Tomonori

2022

Overview

Human induced pluripotent stem cells (hiPSCs) are a promising cell source for elucidating disease pathology and therapy. The mass supply of hiPSC-derived cells is technically feasible. Carriers that can contain a large number of hiPSC-derived cells and evaluate their functions in vivo-like environments will become increasingly important for understanding disease pathogenesis or treating end-stage organ failure. hiPSC-derived hepatocyte-like cells (hiPSC-HLCs; 5 × 108) were seeded into decellularized organ-derived scaffolds under circumfusion culture. The scaffolds were implanted into immunodeficient microminiature pigs to examine their applicability in vivo. The seeded hiPSC-HLCs demonstrated increased albumin secretion and up-regulated cytochrome P450 activities compared with those in standard two-dimensional culture conditions. Moreover, they showed long-term survival accompanied by neovascularization in vivo. The decellularized organ-derived scaffold is a promising carrier for hiPSC-derived cells for ex vivo and in vivo use and is an essential platform for regenerative medicine and research.

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Publisher

MDPI AG,MDPI

Subject

Animals

/ Cell culture

/ Cell Differentiation

/ Cytochrome P450

/ decellularization

/ extracellular matrix

/ Gene expression