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Butyrate acts as a G-protein-coupled receptor ligand that prevents high glucose-induced amyloidogenesis in N2a cells through the protein kinase B/glycogen synthase kinase-3β pathway
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Butyrate acts as a G-protein-coupled receptor ligand that prevents high glucose-induced amyloidogenesis in N2a cells through the protein kinase B/glycogen synthase kinase-3β pathway
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Butyrate acts as a G-protein-coupled receptor ligand that prevents high glucose-induced amyloidogenesis in N2a cells through the protein kinase B/glycogen synthase kinase-3β pathway
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Journal Article
Butyrate acts as a G-protein-coupled receptor ligand that prevents high glucose-induced amyloidogenesis in N2a cells through the protein kinase B/glycogen synthase kinase-3β pathway
2023
Overview
[4] However, there are few studies evaluating the mechanism of NaB on T2DM-related AD. [...]we used mouse neuroblastoma-derived N2a cells (serial TCM29, obtained from National Collection of Authenticated Cell Cultures of China), a cell model extensively used for studying AD-related signal transduction, to investigate the potential impact and mechanism of NaB on high glucose-induced amyloidogenesis. [...]our study found that high glucose treatment decreased activated Akt, which activated GSK-3β and enhanced APP processing, suggesting that high glucose induces amyloidogenesis via GSK-3β signaling. [...]we found the involvement of the Akt/GSK-3β pathway in NaB-mediated anti-amyloidogenesis effect in neuronal cells under high glucose conditions. [...]humans could obtain NaB supplementation by consuming dietary carbohydrates, and diets rich in fiber were reported to decrease brain Aβ and improve memory in AD models and older adults.
Publisher
Lippincott Williams & Wilkins,Lippincott Williams & Wilkins Ovid Technologies,Wolters Kluwer
