Asset Details
Do you wish to reserve the book?
Detoxification of Aflatoxin-Contaminated Maize by Neutral Electrolyzed Oxidizing Water
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Detoxification of Aflatoxin-Contaminated Maize by Neutral Electrolyzed Oxidizing Water
Do you wish to request the book?
Detoxification of Aflatoxin-Contaminated Maize by Neutral Electrolyzed Oxidizing Water
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Detoxification of Aflatoxin-Contaminated Maize by Neutral Electrolyzed Oxidizing Water
2015
Overview
Aflatoxins, a group of extremely toxic mycotoxins produced by Aspergillus flavus, A. parasiticus and A. nomius, can occur as natural contaminants of certain agricultural commodities, particularly maize. These toxins have been shown to be hepatotoxic, carcinogenic, mutagenic and cause severe human and animal diseases. The effectiveness of neutral electrolyzed oxidizing water (NEW) on aflatoxin detoxification was investigated in HepG2 cells using several validation methodologies such as the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay, the induction of lipid peroxidation, the oxidative damage by means of glutathione modulation, the Ames test and the alkaline Comet assay. Our results showed that, after the aflatoxin-contaminated maize containing 360 ng/g was soaked in NEW (60 mg/L available chlorine, pH 7.01) during 15 min at room temperature, the aflatoxin content did not decrease as confirmed by the immunoaffinity column and ultra performance liquid chromatography methods. Aflatoxin fluorescence strength of detoxified samples was similar to untreated samples. However, aflatoxin-associated cytotoxicity and OPEN ACCESS Toxins 2015, 7 4295 genotoxicity effects were markedly reduced upon treatment. According to these results, NEW can be effectively used to detoxify aflatoxin-contaminated maize.
Publisher
Molecular Diversity Preservation International,MDPI AG,MDPI
Subject
/ Aflatoxins - isolation & purification
/ Cell Survival - drug effects
/ Chlorine
/ Corn
/ Dose-Response Relationship, Drug
/ Food Contamination - prevention & control
/ Humans
/ Lipid Peroxidation - drug effects
/ maize
/ neutral electrolyzed oxidizing water
/ Salmonella typhimurium - drug effects
/ Salmonella typhimurium - genetics
/ Toxins
/ Zea mays
