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Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma

by Zhang, Erbao , Xu, Youtao , Xu, Lin , Ma, Zhifei , Cho, William Chi-shing , Dong, Gaochao , Qiu, Mantang , Ma, Patrick C. , Zhang, Quan’an , Popper, Helmut H. , Fang, Tian , Chen, Rui , Metro, Giulio , Wang, Jie , Ujhazy, Peter , Wang, Siwei , Tavolari, Simona , Xu, Weizhang , Xia, Wenjia , Brandi, Giovanni , Yin, Rong

in Adenocarcinoma / Biomarkers / Cell cycle / Cell proliferation / ceRNA / Data analysis / Datasets / Experiments / Gene expression / Genetic engineering / Genomes / Genomics / lncRNA / lung adenocarcinoma / Lung cancer / Lung carcinoma / Ribonucleic acid / RNA / SBF2-AS1 / Squamous cell carcinoma / Therapeutic applications / Tumorigenesis / WGCNA

2019

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Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma

2019

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Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma

2019

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Journal Article

Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma

Zhang, Erbao,

Xu, Youtao,

Xu, Lin,

Ma, Zhifei,

Cho, William Chi-shing,

Dong, Gaochao,

Qiu, Mantang,

Ma, Patrick C.,

Zhang, Quan’an,

Popper, Helmut H.,

Fang, Tian,

Chen, Rui,

Metro, Giulio,

Wang, Jie,

Ujhazy, Peter,

Wang, Siwei,

Tavolari, Simona,

Xu, Weizhang,

Xia, Wenjia,

Brandi, Giovanni,

Yin, Rong

2019

Overview

Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) are deeply involved in the development of various cancers. This study identified that SBF2-AS1, an early-stage-specific lncRNA, is critical for the tumorigenesis of lung adenocarcinoma (LUAD). We first analyzed LUAD transcriptome data from The Cancer Genome Atlas and the GEO database by weighted gene co-expression network analysis (WGCNA). Five early LUAD-specific lncRNAs were filtered out, and only SBF2-AS1 was upregulated in LUAD. High expression of SBF2-AS1 indicates poor survival of LUAD, especially the early-stage LUAD, but not lung squamous cell carcinoma. SBF2-AS1 promotes LUAD cells proliferation in vitro, and RNA-sequencing data shows that many cell-cycle-related genes were downregulated after SBF2-AS1 knockdown. Mechanically, SBF2-AS1 could competitively bind with miR-338-3p and miR-362-3p to increase E2F1 expression. Finally, we show that the SBF2-AS1-miR-338-3p/362-3p-E2F1 axis could promote LUAD tumorigenesis in vitro and in vivo. Our study demonstrates that SBF2-AS1, an early-stage-specific lncRNA, promotes LUAD tumorigenesis by sponging miR-338-3p and miR-362-3p and increasing E2F1 expression. The SBF2-AS1-miR-338-3p/362-3p-E2F1 regulatory axis may serve as a prognostic marker and potential therapeutic target for LUAD.

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Elsevier Inc,Elsevier Limited,American Society of Gene & Cell Therapy,Elsevier

Subject

/ ceRNA