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Follicular lymphoma transformation to dual translocated Burkitt-like lymphoma : improved disease control associated with radiation therapy
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Follicular lymphoma transformation to dual translocated Burkitt-like lymphoma : improved disease control associated with radiation therapy
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Journal Article
Follicular lymphoma transformation to dual translocated Burkitt-like lymphoma : improved disease control associated with radiation therapy
2009
Overview
Dual translocated (or “dual hit”) lymphomas are highly aggressive B cell neoplasms associated with an extremely poor prognosis. The optimal treatment for these lymphomas remains undefined. We present two cases of follicular lymphoma with transformation to Burkitt-like lymphoma. In both cases dual translocations involving both the
bcl-2
and
c-myc
loci were present. Each patient underwent intensive induction immunochemotherapy followed by autologous stem cell transplantation and radiation therapy. The first patient received post-transplant mediastinal radiation and developed recurrence in multiple areas outside of the radiation field. The second patient received total body irradiation as part of the conditioning regimen, and is without recurrence 18 months after transplant, and 24 months after diagnosis of the dual translocated lymphoma. We review dual translocation B cell lymphoma in the setting of transformation from follicular lymphoma, and suggest a potential role for total body irradiation in the management of this highly aggressive non-Hodgkin lymphoma.
Publisher
Springer Japan,Springer,Springer Nature B.V
Subject
Autologous hematopoietic stem cell transplantation
/ Biological and medical sciences
/ Burkitt Lymphoma - pathology
/ Burkitt Lymphoma - radiotherapy
/ Cell Transformation, Neoplastic
/ Hematologic and hematopoietic diseases
/ Humans
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Lymphoma, Follicular - pathology
/ Lymphoma, Follicular - radiotherapy
/ Lymphoma, Follicular - therapy
/ Male
/ Medicine
/ Oncology
/ Proto-Oncogene Proteins c-bcl-2
