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Macrophages and control of granulomatous inflammation in tuberculosis
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Macrophages and control of granulomatous inflammation in tuberculosis
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Journal Article
Macrophages and control of granulomatous inflammation in tuberculosis
2011
Overview
The granuloma that forms in response to Mycobacterium tuberculosis must be carefully balanced in terms of immune responses to provide sufficient immune cell activation to inhibit the growth of the bacilli, yet modulate the inflammation to prevent pathology. There are likely many scenarios by which this balance can be reached, given the complexity of the immune responses induced by M. tuberculosis. In this review, we focus on the key role of the macrophage in balancing inflammation in the granuloma.
Publisher
Elsevier Inc,Nature Publishing Group US,Elsevier Limited
Subject
/ Animals
/ Biomedical and Life Sciences
/ Granuloma, Respiratory Tract - immunology
/ Humans
/ Macrophages, Alveolar - immunology
/ Macrophages, Alveolar - microbiology
/ Mycobacterium tuberculosis - immunology
/ Mycobacterium tuberculosis - pathogenicity
/ review
/ Tuberculosis, Pulmonary - immunology
