Journal Article

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

Pouysségur, J, Meloche, S

2007

Overview

The Ras-dependent extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells, sustained activation of ERK1/ERK2 is necessary for G1- to S-phase progression and is associated with induction of positive regulators of the cell cycle and inactivation of antiproliferative genes. In cells expressing activated Ras or Raf mutants, hyperactivation of the ERK1/2 pathway elicits cell cycle arrest by inducing the accumulation of cyclin-dependent kinase inhibitors. In this review, we discuss the mechanisms by which activated ERK1/ERK2 regulate growth and cell cycle progression of mammalian somatic cells. We also highlight the findings obtained from gene disruption studies.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Publishing Group [1987-....]
• Subject: Animals / Apoptosis / Biochemistry, Molecular Biology / Cancer / Cell activation / Cell Biology / Cell cycle / Cell Proliferation / Cellular signal transduction / Control / Cyclin-dependent kinase / Cyclin-dependent kinase inhibitors / Cyclin-dependent kinases / Enzyme Activation / Enzyme Activation - genetics / Enzyme Activation - physiology / Extracellular signal-regulated kinase / G1 Phase / G1 Phase - genetics / G1 Phase - physiology / Gene disruption / Genetic aspects / Genetics / Human Genetics / Humans / Internal Medicine / Kinases / Life Sciences / Mammals / MAP kinase / MAP Kinase Signaling System / MAP Kinase Signaling System - genetics / MAP Kinase Signaling System - physiology / Medicine / Medicine & Public Health / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 1 - deficiency / Mitogen-Activated Protein Kinase 1 - genetics / Mitogen-Activated Protein Kinase 1 - metabolism / Mitogen-Activated Protein Kinase 1 - physiology / Mitogen-Activated Protein Kinase 3 / Mitogen-Activated Protein Kinase 3 - deficiency / Mitogen-Activated Protein Kinase 3 - genetics / Mitogen-Activated Protein Kinase 3 - metabolism / Mitogen-Activated Protein Kinase 3 - physiology / Oncology / Phase transitions / Physiological aspects / Protein kinase / Protein kinases / Raf protein / Ras protein / review / S Phase / S Phase - genetics / S Phase - physiology / Signal transduction / Somatic cells