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Cellular mechanisms regulating human melanogenesis

by Kosmadaki, M , Yaar, M , Gilchrest, B. A , Park, H. Y

in autocrine signaling / Autocrine signalling / Biochemistry / biogenesis / Biomedical and Life Sciences / Biomedicine / biosynthesis / Cell Biology / Cellular biology / chemistry / dendrites / DNA / DNA Damage / DNA damages / enzymology / Epidermis / Humans / Irradiation / Keratinocytes / Keratinocytes - metabolism / Keratinocytes - radiation effects / Life Sciences / Melanin / Melanins / Melanins - biosynthesis / Melanins - chemistry / Melanocytes / Melanocytes - enzymology / Melanocytes - metabolism / Melanocytes - radiation effects / Melanogenesis / Melanosomes / Melanosomes - enzymology / Melanosomes - metabolism / Melanosomes - radiation effects / metabolism / Models, Biological / Organelles / Paracrine Communication / Paracrine Communication - physiology / Paracrine signalling / physiology / Protein transport / Proteins / radiation effects / Review / Signal Transduction / Synthesis / Tumor Suppressor Protein p53 / Tumor Suppressor Protein p53 - physiology / Ultraviolet radiation / Ultraviolet Rays

2009

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Cellular mechanisms regulating human melanogenesis

by Kosmadaki, M , Yaar, M , Gilchrest, B. A , Park, H. Y

2009

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Cellular mechanisms regulating human melanogenesis

by Kosmadaki, M , Yaar, M , Gilchrest, B. A , Park, H. Y

2009

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Journal Article

Cellular mechanisms regulating human melanogenesis

Kosmadaki, M,

Yaar, M,

Gilchrest, B. A,

Park, H. Y

2009

Overview

The major differentiated function of melanocytes is the synthesis of melanin, a pigmented heteropolymer that is synthesized in specialized cellular organelles termed melanosomes. Mature melanosomes are transferred to neighboring keratinocytes and are arranged in a supranuclear cap, protecting the DNA against incident ultraviolet light (UV) irradiation. The synthesis and distribution of melanin in the epidermis involves several steps: transcription of melanogenic proteins, melanosome biogenesis, sorting of melanogenic proteins into the melanosomes, transport of melanosomes to the tips of melanocyte dendrites and finally transfer into keratinocytes. These events are tightly regulated by a variety of paracrine and autocrine factors in response to endogenous and exogenous stimuli, principally UV irradiation.

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Publisher

Basel : Birkhäuser-Verlag,Birkhäuser-Verlag,Springer Nature B.V

Subject

autocrine signaling

/ Autocrine signalling

/ Biochemistry

/ biogenesis

/ Biomedical and Life Sciences

/ Biomedicine

/ biosynthesis