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The evaluation and management of drug effects on cardiac conduction (PR and QRS Intervals) in clinical development
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The evaluation and management of drug effects on cardiac conduction (PR and QRS Intervals) in clinical development
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Journal Article
The evaluation and management of drug effects on cardiac conduction (PR and QRS Intervals) in clinical development
2013
Overview
Recent advances in electrocardiographic monitoring and waveform analysis have significantly improved the ability to detect drug-induced changes in cardiac repolarization manifested as changes in the QT/corrected QT interval. These advances have also improved the ability to detect drug-induced changes in cardiac conduction. This White Paper summarizes current opinion, reached by consensus among experts at the Cardiac Safety Research Consortium, on the assessment of electrocardiogram-based safety measurements of the PR and QRS intervals, representing atrioventricular and ventricular conduction, respectively, during drug development.
Publisher
Mosby, Inc,Elsevier Limited
Subject
