Journal Article

Acute coronary syndrome: factors predicting smoking cessation

Zemni, Imen, El Hraiech, Aymen, Ben Salah, Arwa, Maatouk, Faouzi, Azaiez, Mohamed, Abroug, Hela, Jomaa, Walid, Ben Fredj, Manel, Mehrez, Ons, Belguith, Asma

2020

Overview

Background: Few randomized controlled trials have examined the efficacy time of smoking cessation in hospitalized patients with acute coronary syndrome, either during hospitalization or after discharge. Aims: To assess smoking cessation rates at 24 weeks among patients with acute coronary syndrome. Group A had begun nicotine replacement therapy during hospitalization, and Group B after discharge. We also determined factors predicting success. Methods: We conducted a randomized controlled trial in the Cardiology Department and Smoking Cessation Service at University Hospital of Monastir, Tunisia from January 2015 to June 2016. Participants were randomly assigned to the above 2 groups. The endpoint assessment was smoking abstinence at 24 weeks, defined as self-reported abstinence in the past week, confirmed by measured exhaled carbon monoxide (CO) [less than or equal to] 8 ppm. We analysed data by intention to treat. We used a binary logistic regression model to determine factors predicting abstinence. Results: All participants were male and mean (standard deviation) age was 55 (11) years. At 24 weeks there was no significant difference in smoking cessation rate between the 2 groups: 54.5% [95% confidence interval (CI): 44.7-64.3%] in Group A and 45.5% (95% CI: 35.7-55.3%) in Group B (P = 0.81). High level of nicotine dependence [odds ratio (OR): 0.72; 95% CI: 0.54-0.96) and good compliance during follow-up (OR: 6.56; 95% CI: 2.07-20.78) were predictive factors for abstinence. Conclusions: Smoking cessation rate after acute coronary syndrome was high regardless of the start date. Good compliance during follow-up was the key predictive factor for success.

• Publisher: World Health Organization
• Subject: Acute coronary syndromes / Carbon monoxide / Cardiac patients / Cardiology / Cardiovascular disease / Cigarette smoking / Clinical trials / Confidence intervals / Coronary heart disease / Discharge / Drug addiction / Drug dependence / Heart attacks / Hospital patients / Medical research / Motivation / Nicotine / Randomization / Regression analysis / Regression models / Sexual behavior / Smoking / Smoking cessation / Smoking cessation products / Standard deviation / Statistical analysis / Time / Transdermal medication / Varenicline