Asset Details
Do you wish to reserve the book?
SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians
Do you wish to request the book?
SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians
2018
Overview
Mechanisms underlying anteroposterior body axis differences during adult tissue maintenance and regeneration are poorly understood. Here, we identify that post-translational modifications through the SUMO (Small Ubiquitin-like Modifier) machinery are evolutionarily conserved in the Lophotrocozoan
Schmidtea mediterranea
. Disruption of SUMOylation in adult animals by RNA-interference of the only SUMO E2 conjugating enzyme
Ubc9
leads to a systemic increase in DNA damage and a remarkable regional defect characterized by increased cell death and loss of the posterior half of the body. We identified that
Ubc9
is mainly expressed in planarian stem cells (neoblasts) but it is also transcribed in differentiated cells including neurons. Regeneration in
Ubc9
(
RNAi
) animals is impaired and associated with low neoblast proliferation. We present evidence indicating that
Ubc9
-induced regional cell death is preceded by alterations in transcription and spatial expression of repressors and activators of the Hedgehog signaling pathway. Our results demonstrate that SUMOylation acts as a regional-specific cue to regulate cell fate during tissue renewal and regeneration.
Publisher
Springer International Publishing,Springer Nature B.V
Subject
/ Animals
/ Biomedical and Life Sciences
/ DNA
/ Hedgehog Proteins - genetics
/ Hedgehog Proteins - metabolism
/ Helminth Proteins - classification
/ Helminth Proteins - genetics
/ Helminth Proteins - metabolism
/ neurons
/ post-translational modification
/ RNA
/ Sequence Homology, Amino Acid
/ Small Ubiquitin-Related Modifier Proteins - classification
/ Small Ubiquitin-Related Modifier Proteins - genetics
/ Small Ubiquitin-Related Modifier Proteins - metabolism
/ Ubiquitin-Conjugating Enzymes - classification
