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Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

by Coughlan, Lynda , Berthoud, Tamara K , Antrobus, Richard D , Gilbert, Sarah C , Hill, Adrian VS , Dicks, Matthew D , Lambe, Teresa

in Adenovirus / Adenoviruses / Adenoviruses, Simian - genetics / Adolescent / Adult / Animals / Antibodies / Antigens / Antigens, Viral - immunology / Clinical trials / Dose-Response Relationship, Immunologic / Genetic Vectors - administration & dosage / Genetic Vectors - adverse effects / HEK293 Cells / Human adenovirus / Humans / Influenza A virus - metabolism / Influenza Vaccines - administration & dosage / Influenza Vaccines - adverse effects / Influenza Vaccines - immunology / Middle Aged / Monkeys & apes / Nucleocapsid Proteins / Original / Pan troglodytes / Pan troglodytes - virology / Peptides / Proteins / Recombinant Proteins - immunology / Recombinant Proteins - metabolism / RNA-Binding Proteins - immunology / RNA-Binding Proteins - metabolism / Serology / Vaccination - adverse effects / Vaccines / Vaccinia virus / Viral Core Proteins - immunology / Viral Core Proteins - metabolism / Viral Matrix Proteins - immunology / Viral Matrix Proteins - metabolism / Virus Replication - immunology / Viruses / Volunteers / Young Adult

2014

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Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

by Coughlan, Lynda , Berthoud, Tamara K , Antrobus, Richard D , Gilbert, Sarah C , Hill, Adrian VS , Dicks, Matthew D , Lambe, Teresa

2014

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Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

by Coughlan, Lynda , Berthoud, Tamara K , Antrobus, Richard D , Gilbert, Sarah C , Hill, Adrian VS , Dicks, Matthew D , Lambe, Teresa

2014

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Journal Article

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

Coughlan, Lynda,

Berthoud, Tamara K,

Antrobus, Richard D,

Gilbert, Sarah C,

Hill, Adrian VS,

Dicks, Matthew D,

Lambe, Teresa

2014

Overview

Adenoviruses are potent vectors for inducing and boosting cellular immunity to encoded recombinant antigens. However, the widespread seroprevalence of neutralizing antibodies to common human adenovirus serotypes limits their use. Simian adenoviruses do not suffer from the same drawbacks. We have constructed a replication-deficient chimpanzee adenovirus-vectored vaccine expressing the conserved influenza antigens, nucleoprotein (NP), and matrix protein 1 (M1). Here, we report safety and T-cell immunogenicity following vaccination with this novel recombinant simian adenovirus, ChAdOx1 NP+M1, in a first in human dose-escalation study using a 3+3 study design, followed by boosting with modified vaccinia virus Ankara expressing the same antigens in some volunteers. We demonstrate ChAdOx1 NP+M1 to be safe and immunogenic. ChAdOx1 is a promising vaccine vector that could be used to deliver vaccine antigens where strong cellular immune responses are required for protection.

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Publisher

Elsevier Inc,Elsevier Limited,Nature Publishing Group

Subject

Adenovirus

/ Adenoviruses

/ Adenoviruses, Simian - genetics

/ Adolescent

/ Adult

/ Animals

/ Antibodies