Journal Article

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Wan, Dongshan, Jiang, Wei, Hao, Junwei

2020

Overview

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN) inflammatory signaling responses and other cellular processes such as autophagy, cell survival, senescence. cGAS-STING pathway interplays with other innate immune pathways, by which it participates in regulating infection, inflammatory disease, and cancer. The therapeutic approaches targeting this pathway show promise for future translation into clinical applications. Here, we present a review of the important previous works and recent advances regarding the cGAS-STING pathway, and provide a comprehensive understanding of the modulatory pattern of the cGAS-STING pathway under multifarious pathologic states.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Adenosine triphosphate / Autophagy / Autophagy - physiology / Binding sites / Cell Survival / Cellular Senescence / cGAMP / cGAS / Cytoplasm / DNA - metabolism / Humans / Immunity (Disease) / Immunology / Infections - immunology / inflammation / Inflammation - etiology / Inflammatory diseases / Interferon / Interferon Type I - physiology / Ligands / Membrane Proteins - physiology / Mitochondrial DNA / Neoplasms - immunology / Nucleotidyltransferases - physiology / Pathogens / Permeability / Proteins / Senescence / Signal Transduction - drug effects / Signal Transduction - physiology / STING / Transcription factors / type I interferonopathies