Journal Article

Modulation of Host-Pathogen Communication by Extracellular Vesicles (EVs) of the Protozoan Parasite Leishmania

Dong, George, Olivier, Martin, Filho, Alonso Lira

2019

Overview

genus protozoan parasites have developed various strategies to overcome host cell protective mechanisms favoring their survival and propagation. Recent findings in the field propose a new player in this infectious strategy, the exosomes. Exosomes are eukaryotic extracellular vesicles essential to cell communication in various biological contexts. In fact, there have been an increasing number of reports over the last 10 years regarding the role of protozoan parasite exosomes, exosomes included, in their capacity to favor infection and propagation within their hosts. In this review, we will discuss the latest findings regarding exosome function during infectious conditions with a strong focus on -host interaction from a mammalian perspective. We also compare the immunomodulatory properties of exosomes to other parasite exosomes, demonstrating the conserved, important role that exosomes play during parasite infection.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Animals / Cell interactions / Cellular and Infection Microbiology / Eukaryotes / exosome / Exosomes / Extracellular vesicles / Extracellular Vesicles - metabolism / host-pathogen interaction / Host-Pathogen Interactions - drug effects / Humans / Immune Evasion / Immunologic Factors - metabolism / Immunomodulation / Leishmania / Leishmania - growth & development / Leishmania - metabolism / macrophage / Parasites / Parasitic diseases / Protozoa / Virulence Factors - metabolism