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Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae
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Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae
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Journal Article
Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae
2018
Overview
is a Gram-negative pathogen that has a large accessory genome of plasmids and chromosomal gene loci. This accessory genome divides
strains into opportunistic, hypervirulent, and multidrug-resistant groups and separates
from two closely related species,
and
. Some strains of
act as opportunistic pathogens, infecting critically ill and immunocompromised patients. These
are a common cause of health-care associated infections including pneumonia, urinary tract infections (UTIs), and bloodstream infections.
and
are often clinically indistinguishable from opportunistic
. Other strains of
are hypervirulent, infecting healthy people in community settings and causing severe infections including pyogenic liver abscess, endophthalmitis, and meningitis. A third group of
encode carbapenemases, making them highly antibiotic-resistant. These strains act as opportunists but are exceedingly difficult to treat. All of these groups of
and related species can colonize the gastrointestinal tract, and the accessory genome may determine if a colonizing strain remains asymptomatic or progresses to cause disease. This review will explore the associations between colonization and infection with opportunistic, antibiotic-resistant, and hypervirulent
strains and the role of the accessory genome in distinguishing these groups and related species. As
infections become progressively more difficult to treat in the face of antibiotic resistance and hypervirulent strains, an increased understanding of the epidemiology and pathogenesis of these bacteria is vital.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Community-Acquired Infections - microbiology
/ Cross Infection - microbiology
/ Diabetes
/ Feces
/ Genomes
/ Humans
/ Klebsiella Infections - epidemiology
/ Klebsiella Infections - microbiology
/ Klebsiella pneumoniae - drug effects
/ Klebsiella pneumoniae - pathogenicity
/ Klebsiella pneumoniae - physiology
/ Mucous Membrane - microbiology
/ Opportunistic Infections - microbiology
/ Plasmids
