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Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging
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Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging
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Journal Article
Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging
2016
Overview
Objective： Photoacoustic （PA） tomography （PAT） has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human body. Methods： In this study, we presented a PA contrast agent： 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy （polyethylene glycol）] （DSPE-PEG）-coated superparamagnetic iron oxide （SPIO） nanoparticles （NPs） loaded with indocyanine green （ICG）. We used ICG and SPIO NPs because both drugs are approved by the U.S. Food and Drug Administration. Given the strong absorption of near-infrared laser pulses, SPIO@DSPE-PEG/ICG NPs with a uniform diameter of -28 nm could significantly enbance PA signals. Results： We demonstrated the contrast enhancement of these NPs in phantom and animal experiments, in which the in vivo circulation time of SPIO@DSPE-PEG/ICG NPs was considerably longer than that of free ICG. These novel NPs also displayed a high efficiency of tumor targeting. Conclusions： SPIO@DSPE-PEG/ICG NPs are promising PAT contrast agents for clinical applications.
Publisher
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China%Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China%Nanomedicine and Biosensor Laboratory, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China,Chinese Anti-Cancer Association,China Anti-Cancer Association
