Journal Article

The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System

Wang, Shukun, Dong, Yuan, Cheng, Jinbo, Yuan, Zengqiang

2020

Overview

The Hippo signaling pathway, an evolutionarily conserved protein kinase cascade, plays a critical role in controlling organ size, cancer development, and tissue regeneration. Recently, mounting evidence has suggested that Hippo signaling also has an important role in regulating immunity, including innate and adaptive immune activation. In the neuronal system, Our laboratory results, together with those from other studies, demonstrate that the Hippo signaling pathway is involved in neuroinflammation, neuronal cell differentiation, and neuronal death. In the present review, we summarize the recent findings pertaining to the function and regulatory mechanism of Hippo signaling components in the neuronal system, implicating the potential of Hippo signaling as a therapeutic target for the treatment of neuronal system diseases.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Animals / Apoptosis / Cell Death / Cell differentiation / Cell division / Cell growth / diseases / Genes / Hippo signaling / Humans / Immune response / Immunity (Disease) / Immunology / Inflammation - etiology / Insects / Kinases / Nervous System Diseases - etiology / Neural Stem Cells - physiology / neuroinflammation / neuronal system / Neurons / Neurons - physiology / Oxidative stress / Phosphorylation / Protein kinase C / Protein-Serine-Threonine Kinases - physiology / Proteins / Regeneration / Regulation / Signal transduction / Signal Transduction - drug effects / Signal Transduction - physiology / Stem cells / Therapeutic targets / Transcription factors