Asset Details
Do you wish to reserve the book?
Eosinophil Extracellular Traps and Inflammatory Pathologies—Untangling the Web
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Eosinophil Extracellular Traps and Inflammatory Pathologies—Untangling the Web
Do you wish to request the book?
Eosinophil Extracellular Traps and Inflammatory Pathologies—Untangling the Web
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Eosinophil Extracellular Traps and Inflammatory Pathologies—Untangling the Web
2018
Overview
Eosinophils are an enigmatic white blood cell, whose immune functions are still under intense investigation. Classically, the eosinophil was considered to fulfill a protective role against parasitic infections, primarily large multicellular helminths. Although eosinophils are predominantly associated with parasite infections, evidence of a role for eosinophils in mediating immunity against bacterial, viral, and fungal infections has been recently reported. Among the mechanisms by which eosinophils are proposed to exert their protective effects is the production of DNA-based extracellular traps (ETs). Remarkably, DNA serves a role that extends beyond its biochemical function in encoding RNA and protein sequences; it is also a highly effective substance for entrapment of bacteria and other extracellular pathogens, and serves as valuable scaffolding for antimicrobial mediators such as granule proteins from immune cells. Extracellular trap formation from eosinophils appears to fulfill an important immune response against extracellular pathogens, although overproduction of traps is evident in pathologies. Here, we discuss the discovery and characterization of eosinophil extracellular traps (EETs) in response to a variety of stimuli, and suggest a role for these structures in the pathogenesis of disease as well as the establishment of autoimmunity in chronic, unresolved inflammation.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Animals
/ Asthma
/ Chronic obstructive pulmonary disease
/ Cytoplasmic Granules - immunology
/ ETosis
/ Extracellular Traps - immunology
/ Humans
/ Hypersensitivity, Immediate - immunology
/ Hypersensitivity, Immediate - pathology
/ Inflammation Mediators - immunology
/ Proteins
/ Pulmonary Disease, Chronic Obstructive - immunology
/ Pulmonary Disease, Chronic Obstructive - pathology
/ Traps
