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Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
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Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
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Journal Article
Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
2007
Overview
Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Biological and medical sciences
/ Fundamental and applied biological sciences. Psychology
/ Genic rearrangement. Recombination. Transposable element
/ genome
/ Genomes
/ Genomics
/ Mammals
/ MicroRNA
/ Molecular and cellular biology
/ Proteins
/ Review
/ RNA
/ RNA-Binding Proteins - genetics
/ RNA-Binding Proteins - physiology
