Asset Details
Do you wish to reserve the book?
Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment
Do you wish to request the book?
Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment
2019
Overview
Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that catalyze post-translational deimination/citrullination of proteins, causing structural and functional changes in target proteins. PADs also play major roles in the regulation of eukaryotic extracellular vesicle release. Here we show phylogenetically conserved pathways of PAD-mediated OMV/MV release in bacteria and describe deiminated/citrullinated proteins in
and their derived OMV/MVs. Furthermore, we show that PAD inhibitors can be used to effectively reduce OMV/MV release, both in Gram-negative and Gram-positive bacteria. Importantly, this resulted in enhanced antibiotic sensitivity of both
and
to a range of antibiotics tested. Our findings reveal novel strategies for applying pharmacological OMV/MV-inhibition to reduce antibiotic resistance.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Bacterial Proteins - metabolism
/ Cellular and Infection Microbiology
/ E coli
/ Enzyme Inhibitors - pharmacology
/ Escherichia coli - drug effects
/ Escherichia coli - metabolism
/ Extracellular Vesicles - drug effects
/ Extracellular Vesicles - metabolism
/ Microbial Viability - drug effects
/ outer-membrane vesicles (OMVs)
/ peptidylarginine deiminase (PAD)
/ Protein Processing, Post-Translational
/ Protein-Arginine Deiminases - drug effects
/ RNA
/ S. aureus subsp. aureus Rosenbach
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - metabolism
