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Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering
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Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering
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Journal Article
Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering
2021
Overview
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their low immunogenicity and ability to functionally modify recipient cells by transferring diverse bioactive constituents make them an excellent candidate for a next‐generation drug delivery system. Here, the recent advances in EV biology and emerging strategies of EV bioengineering are summarized, and the prospects for clinical translation of bioengineered EVs and the challenges to be overcome are discussed. Extracellular vesicles (EVs) managing diverse intercellular communication networks are attracting increasing interest in developing next‐generation drug delivery systems. This review provides a comprehensive state‐of‐the‐art coverage of EV biogenesis, transport, release, and uptake as well as cargo sorting and discusses the progress and challenges of engineering EVs for therapeutic applications.
