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Sumoylation promotes optimal APC/C activation and timely anaphase
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Journal Article
Sumoylation promotes optimal APC/C activation and timely anaphase
2018
Overview
The Anaphase Promoting Complex/Cyclosome (APC/C) is a ubiquitin E3 ligase that functions as the gatekeeper to mitotic exit. APC/C activity is controlled by an interplay of multiple pathways during mitosis, including the spindle assembly checkpoint (SAC), that are not yet fully understood. Here, we show that sumoylation of the APC4 subunit of the APC/C peaks during mitosis and is critical for timely APC/C activation and anaphase onset. We have also identified a functionally important SUMO interacting motif in the cullin-homology domain of APC2 located near the APC4 sumoylation sites and APC/C catalytic core. Our findings provide evidence of an important regulatory role for SUMO modification and binding in affecting APC/C activation and mitotic exit.
Publisher
eLife Science Publications, Ltd,eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
Subject
/ Anaphase-Promoting Complex-Cyclosome - chemistry
/ Anaphase-Promoting Complex-Cyclosome - genetics
/ APC/C
/ APC4
/ Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry
/ Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics
/ Cullin
/ Cytoskeletal Proteins - chemistry
/ Cytoskeletal Proteins - genetics
/ Enzymes
/ Homology
/ Humans
/ Kinases
/ Ligases
/ M Phase Cell Cycle Checkpoints - genetics
/ Mitosis
/ Post-translational modifications
/ Proteins
/ Software
/ Spindle Apparatus - chemistry
/ Spindle Apparatus - genetics
/ SUMO
