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Importance of Fluorine in Benzazole Compounds
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Journal Article
Importance of Fluorine in Benzazole Compounds
2020
Overview
Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to non-fluorinated molecules. In this short review, we will highlight the importance of incorporating fluorine as a basic appendage in benzothiazole and benzimidazole skeletons. The chemistry and pharmacological activities of heterocycles containing fluorine during the past years are compiled and discussed.
Publisher
MDPI AG,MDPI
Subject
Agammaglobulinaemia Tyrosine Kinase - antagonists & inhibitors
/ Benzimidazoles - pharmacology
/ Benzothiazoles - pharmacology
/ Cancer
/ Chemistry, Pharmaceutical - methods
/ Enzyme Inhibitors - chemistry
/ Enzyme Inhibitors - pharmacology
/ Fluorine
/ Heterocyclic Compounds, 2-Ring - chemistry
/ Heterocyclic Compounds, 2-Ring - pharmacology
/ Humans
/ Hydrogen
/ Review
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