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Alpha-2-Macroglobulin in Inflammation, Immunity and Infections
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Alpha-2-Macroglobulin in Inflammation, Immunity and Infections
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Journal Article
Alpha-2-Macroglobulin in Inflammation, Immunity and Infections
2021
Overview
Alpha-2-macroglobulin is an extracellular macromolecule mainly known for its role as a broad-spectrum protease inhibitor. By presenting itself as an optimal substrate for endopeptidases of all catalytic types, alpha-2-macroglobulin lures active proteases into its molecular cage and subsequently ‘flags’ their complex for elimination. In addition to its role as a regulator of extracellular proteolysis, alpha-2-macroglobulin also has other functions such as switching proteolysis towards small substrates, facilitating cell migration and the binding of cytokines, growth factors and damaged extracellular proteins. These functions appear particularly important in the context of immune-cell function. In this review manuscript, we provide an overview of all functions of alpha-2-macroglobulin and place these in the context of inflammation, immunity and infections.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Animals
/ Antigens
/ Communicable Diseases - diagnosis
/ Communicable Diseases - etiology
/ Communicable Diseases - metabolism
/ Complement Activation - genetics
/ Complement Activation - immunology
/ Complement System Proteins - immunology
/ Humans
/ Immunity
/ Intercellular Signaling Peptides and Proteins - metabolism
/ Lectins
/ Pregnancy-Associated alpha 2-Macroglobulins - genetics
/ Pregnancy-Associated alpha 2-Macroglobulins - metabolism
/ Proteins
