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The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview
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The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview
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Journal Article
The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview
2016
Overview
Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than 100 years ago. The peculiar cone-like conformation of the sugar ring, expressing a lipophilic cavity and a hydrophilic external surface, allows these substances to spontaneously complex poorly soluble compounds in an aqueous environment. For more than 50 years, these substances have found applicability in the pharmaceutical and food industries as solubilizing agents for poorly soluble chemical entities. Nowadays, several research groups all over the world are investigating their potential as active pharmaceutical ingredients (APIs) for the treatment of several illnesses (e.g., hypercholesterolemia, cancer, Niemann-Pick Type C disease). The aim of this review is to briefly retrace cyclodextrins’ legacy as complexing agents and describe the current and future prospects of this class of chemical entities in pharmaceutics as new APIs.
Publisher
MDPI AG,MDPI
Subject
/ Anticholesteremic Agents - chemistry
/ Anticholesteremic Agents - therapeutic use
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - therapeutic use
/ Cyclodextrins - therapeutic use
/ Energy
/ Enzymes
/ Glucose
/ Humans
/ Hypercholesterolemia - drug therapy
/ Hypercholesterolemia - physiopathology
/ Ligands
/ Neuroprotective Agents - chemistry
/ Neuroprotective Agents - therapeutic use
/ Niemann-Pick Disease, Type C - drug therapy
/ Niemann-Pick Disease, Type C - physiopathology
/ Niemann-Pick Type C disease treatment
/ Review
