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High-Throughput Genetic Analysis Using Microfabricated 96-Sample Capillary Array Electrophoresis Microplates
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High-Throughput Genetic Analysis Using Microfabricated 96-Sample Capillary Array Electrophoresis Microplates
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High-Throughput Genetic Analysis Using Microfabricated 96-Sample Capillary Array Electrophoresis Microplates
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Journal Article
High-Throughput Genetic Analysis Using Microfabricated 96-Sample Capillary Array Electrophoresis Microplates
1998
Overview
Capillary array electrophoresis (CAE) microplates that can analyze 96 samples in less than 8 min have been produced by bonding 10-cm-diameter micromachined glass wafers to form a glass sandwich structure. The microplate has 96 sample wells and 48 separation channels with an injection unit that permits the serial analysis of two different samples on each capillary. An elastomer sheet with an 8 by 12 array of holes is placed on top of the glass sandwich structure to define the sample wells. Samples are addressed with an electrode array that makes up the third layer of the assembly. Detection of all lanes with high temporal resolution was achieved by using a laser-excited confocal fluorescence scanner. To demonstrate the functionality of these microplates, electrophoretic separation and fluorescence detection of a restriction fragment marker for the diagnosis of hereditary hemochromatosis were performed. CAE microplates will facilitate all types of high-throughput genetic analysis because their high assay speed provides a throughput that is 50 to 100 times greater than that of conventional slab gels.
Publisher
National Academy of Sciences of the United States of America,The National Academy of Sciences,National Academy of Sciences
Subject
/ Biophysics and Computational Biology
/ Cathodes
/ DNA
/ Electrophoresis - instrumentation
/ Gels
/ Genetics
/ Histocompatibility Antigens Class I - biosynthesis
/ Histocompatibility Antigens Class I - genetics
/ Humans
/ Microchemistry - instrumentation
/ Physics
