Journal Article

Trypsin inhibitors: promising candidate satietogenic proteins as complementary treatment for obesity and metabolic disorders?

Piuvezam, Grasiela, Leal Lima Maciel, Bruna, Cristina Oliveira de Lima, Vanessa, Heloneida de Araújo Morais, Ana

2019

Overview

The increase in non-communicable chronic diseases has aroused interest in the research of adjuvants to the classic forms of treatments. Obesity and metabolic syndrome are the main targets of confrontation because they relate directly to other chronic diseases. In this context, trypsin inhibitors, molecules with wide heterologous application, appear as possibilities in the treatment of overweight and obesity due to the action on satiety related mechanisms, mainly in the modulation of satiety hormones, such as cholecystokinin. In addition, trypsin inhibitors have the ability to also act on some biochemical parameters related to these diseases, thus, emerging as potential candidates and promising molecules in the treatment of the obesity and metabolic syndrome. Thus, the present article proposes to approach, through a systematic literature review, the advantages, disadvantages and viabilities for the use of trypsin inhibitors directed to the treatment of overweight and obesity.

• Publisher: Taylor & Francis,Taylor & Francis Ltd,Taylor & Francis Group
• Subject: Adjuvants / Body weight / Cholecystokinin / Chronic illnesses / Dose-Response Relationship, Drug / hormones / Humans / Literature reviews / Metabolic Diseases - drug therapy / Metabolic disorders / Metabolic syndrome / Molecular Structure / Non-communicable diseases / Obesity / Obesity - drug therapy / Overweight / Review / Satiety / satiety response / Structure-Activity Relationship / Trypsin / Trypsin - metabolism / trypsin inhibitor / Trypsin Inhibitors - chemical synthesis / Trypsin Inhibitors - chemistry / Trypsin Inhibitors - pharmacology