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A plain language summary publication of patients’ survival with endometrial cancer treated with dostarlimab plus carboplatin-paclitaxel
by
Bjørge, Line
, Herzog, Thomas J.
, Boere, Ingrid
, Willmott, Lyndsay
, Monk, Bradley J.
, Buscema, Joseph
, Balas, Morad Marco
, Coleman, Robert L.
, Ring, Kari L.
, Lai, Dominic W.
, McCourt, Carolyn
, Black, Destin
, Powell, Matthew A.
, Landrum, Lisa M.
, Grimshaw, Matthew
, Stuckey, Ashley
, Gilbert, Lucy
, Stevens, Shadi
, Mirza, Mansoor Raza
, Gropp-Meier, Martina
, Shahin, Mark S.
, Sebastianelli, Alexandra
, Pothuri, Bhavana
, Segev, Yakir
, Sharma, Sudarshan
, Gold, Michael A.
, Slomovitz, Brian M.
, Gill, Sarah E.
, Gennigens, Christine
, Valabrega, Giorgio
, Novák, Zoltán
in
Biomarkers
/ Carboplatin
/ Endometrial cancer
/ Endometrium
/ Human health sciences
/ Oncologie
/ Oncology
/ Paclitaxel
/ Placebos
/ Plain Language Summary of Publication
/ Sciences de la santé humaine
/ Uterine cancer
2025
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A plain language summary publication of patients’ survival with endometrial cancer treated with dostarlimab plus carboplatin-paclitaxel
by
Bjørge, Line
, Herzog, Thomas J.
, Boere, Ingrid
, Willmott, Lyndsay
, Monk, Bradley J.
, Buscema, Joseph
, Balas, Morad Marco
, Coleman, Robert L.
, Ring, Kari L.
, Lai, Dominic W.
, McCourt, Carolyn
, Black, Destin
, Powell, Matthew A.
, Landrum, Lisa M.
, Grimshaw, Matthew
, Stuckey, Ashley
, Gilbert, Lucy
, Stevens, Shadi
, Mirza, Mansoor Raza
, Gropp-Meier, Martina
, Shahin, Mark S.
, Sebastianelli, Alexandra
, Pothuri, Bhavana
, Segev, Yakir
, Sharma, Sudarshan
, Gold, Michael A.
, Slomovitz, Brian M.
, Gill, Sarah E.
, Gennigens, Christine
, Valabrega, Giorgio
, Novák, Zoltán
in
Biomarkers
/ Carboplatin
/ Endometrial cancer
/ Endometrium
/ Human health sciences
/ Oncologie
/ Oncology
/ Paclitaxel
/ Placebos
/ Plain Language Summary of Publication
/ Sciences de la santé humaine
/ Uterine cancer
2025
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A plain language summary publication of patients’ survival with endometrial cancer treated with dostarlimab plus carboplatin-paclitaxel
by
Bjørge, Line
, Herzog, Thomas J.
, Boere, Ingrid
, Willmott, Lyndsay
, Monk, Bradley J.
, Buscema, Joseph
, Balas, Morad Marco
, Coleman, Robert L.
, Ring, Kari L.
, Lai, Dominic W.
, McCourt, Carolyn
, Black, Destin
, Powell, Matthew A.
, Landrum, Lisa M.
, Grimshaw, Matthew
, Stuckey, Ashley
, Gilbert, Lucy
, Stevens, Shadi
, Mirza, Mansoor Raza
, Gropp-Meier, Martina
, Shahin, Mark S.
, Sebastianelli, Alexandra
, Pothuri, Bhavana
, Segev, Yakir
, Sharma, Sudarshan
, Gold, Michael A.
, Slomovitz, Brian M.
, Gill, Sarah E.
, Gennigens, Christine
, Valabrega, Giorgio
, Novák, Zoltán
in
Biomarkers
/ Carboplatin
/ Endometrial cancer
/ Endometrium
/ Human health sciences
/ Oncologie
/ Oncology
/ Paclitaxel
/ Placebos
/ Plain Language Summary of Publication
/ Sciences de la santé humaine
/ Uterine cancer
2025
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A plain language summary publication of patients’ survival with endometrial cancer treated with dostarlimab plus carboplatin-paclitaxel
Journal Article
A plain language summary publication of patients’ survival with endometrial cancer treated with dostarlimab plus carboplatin-paclitaxel
2025
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Overview
Summary
What is the purpose of this PLS-P?
The purpose of this plain language summary of publication is to help you understand recent findings from Part 1 of the RUBY study (full name ENGOT-EN6/GOG3031/RUBY trial).
• Researchers sometimes study new combinations of already approved individual treatments to see if the combinations work well together and if they are safe to prescribe to patients.
• In Part 1 of the RUBY study, the combination of dostarlimab with carboplatin-paclitaxel was investigated to see how well it worked for patients with primary advanced or recurrent endometrial cancer when compared with patients who were given placebo plus carboplatin-paclitaxel.
• Patients in the RUBY study were divided into subgroups according to their biomarker status. This allowed researchers to see if biomarker status could help determine how well patients with specific biomarkers would respond to the combination of dostarlimab with carboplatin-paclitaxel.
• This summary reports the results of the second data cut (the second time investigators looked at all of the data since the start of the study) of the RUBY study. At this time, researchers were looking specifically at how long patients lived and how safe the treatment was in patients who received dostarlimab with carboplatin-paclitaxel compared with those patients who received placebo plus carboplatin-paclitaxel.
Publisher
SAGE Publications,Sage Publications Ltd,SAGE Publishing
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