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Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles
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Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles
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Journal Article
Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles
2020
Overview
A facile, one-pot, and proficient method was developed for the production of various 2-arylaminobenzimidazoles. This methodology is based for the first time on a copper catalyst promoted domino C-N cross-coupling reaction for the generation of 2-arylaminobenzimidazoles. Mechanistic investigations revealed that the synthetic pathway involves a copper-based desulphurization/nucleophilic substitution and a subsequent domino intra and intermolecular C-N cross-coupling reactions. Some of the issues typically encountered during the synthesis of 2-arylaminobezimidazoles, including the use of expensive catalytic systems and the low reactivity of bromo precursors, were addressed using this newly developed copper-catalyzed method. The reaction procedure is simple, generally with excellent substrate tolerance, and provides good to high yields of the desired products.
Publisher
MDPI AG,MDPI
