Asset Details
Do you wish to reserve the book?
Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms
Do you wish to request the book?
Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms
2019
Overview
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it may cause damage to healthy tissue, with both short-term and long-term side effects. Severe radiation-induced normal tissue damage (RINTD) frequently has a significant influence on the progress of RT and the survival and prognosis of patients. The redox system has been shown to play an important role in the early and late effects of RINTD. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the main sources of RINTD. The free radicals produced by irradiation can upregulate several enzymes including nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), lipoxygenases (LOXs), nitric oxide synthase (NOS), and cyclooxygenases (COXs). These enzymes are expressed in distinct ways in various cells, tissues, and organs and participate in the RINTD process through different regulatory mechanisms. In recent years, several studies have demonstrated that epigenetic modulators play an important role in the RINTD process. Epigenetic modifications primarily contain noncoding RNA regulation, histone modifications, and DNA methylation. In this article, we will review the role of oxidative stress and epigenetic mechanisms in radiation damage, and explore possible prophylactic and therapeutic strategies for RINTD.
Publisher
Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc
Subject
/ Cancer
/ DNA
/ Enzymes
/ Epigenesis, Genetic - radiation effects
/ Gene Expression Regulation, Enzymologic - radiation effects
/ Gene Expression Regulation, Neoplastic - radiation effects
/ Humans
/ Oxidases
/ Oxidative Stress - radiation effects
/ Oxidoreductases - biosynthesis
/ Radiation Injuries - enzymology
/ Radiation Injuries - pathology
/ Radiotherapy - adverse effects
/ Reactive Oxygen Species - metabolism
/ Review
