Asset Details
Do you wish to reserve the book?
The effect of exosome-related therapy in cardiac revascularization procedures: a systematic review
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The effect of exosome-related therapy in cardiac revascularization procedures: a systematic review
Do you wish to request the book?
The effect of exosome-related therapy in cardiac revascularization procedures: a systematic review
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The effect of exosome-related therapy in cardiac revascularization procedures: a systematic review
2025
Overview
Background
Cardiovascular diseases (CVDs) remain the leading global cause of mortality despite advances in revascularization strategies like coronary artery bypass grafting (CABG) and percutaneous interventions. Exosomes have emerged as dual-function agents, acting both as paracrine mediators of vascular repair and as drug-delivery vehicles. This systematic review evaluates the therapeutic efficacy of exosome-based therapies in cardiac revascularization procedures.
Methods
A comprehensive search of Embase, PubMed, Scopus, and Web of Science was conducted from inception to January 2025. We included experimental studies, evaluating animal subjects undergoing revascularizations. Risk of bias was assessed using SYRCLE’s tool. Study characteristics, population characteristics, intervention details, various outcomes, and limitations of each study were extracted from each included study.
Results
Eight preclinical studies met our inclusion criteria. We observed that exosome therapies demonstrated significant benefits. Sirolimus-loaded exosomes (SIR-EXO) reduced stenosis to 5% vs. 59% in controls. Exosome-coated stents (ACC-Exo-REDV) suppressed neointimal hyperplasia by 60% compared to bare stents. Brown adipose tissue-derived exosomes increased left ventricular ejection fraction, while CABG + exosome patches restored diastolic function. Exosome-eluting stents reduced pro-inflammatory cytokines (IL-1β, TNF-α) by 93% and promoted M2 macrophage polarization. Exosome-enhanced stents improved endothelial cell proliferation by 40% and reduced platelet adhesion by 70%.
Conclusion
Exosome-based therapies show promise in enhancing vascular repair, mitigating restenosis, and modulating post-revascularization inflammation.
Publisher
BioMed Central,BioMed Central Ltd,BMC
