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Fabrication of fillable microparticles and other complex 3D microstructures

by Taylor, Matthew A. , Behrens, Adam M. , Jaklenec, Ana , Nguyen, Thanh D. , Norman, James J. , Linehan, Allison R. , Xu, Xian , Langer, Robert , Yang, David , Guarecuco, Rohiverth , Lu, Jennifer , McHugh, Kevin J. , Tomasic, Stephanie , Tochka, Zachary L. , Tzeng, Stephany Y. , Rose, Sviatlana , Anselmo, Aaron C.

in Biocompatibility / Biomedical materials / Copolymers / Drug delivery / Fabrication / Manufacturing / Materials Science / Microfluidic devices / Microfluidics / Microparticles / Microstructure / pH effects / pH sensors / Pharmacology / Polymers / Printing / Side effects / Three dimensional printing

2017

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Fabrication of fillable microparticles and other complex 3D microstructures

2017

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Fabrication of fillable microparticles and other complex 3D microstructures

2017

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Journal Article

Fabrication of fillable microparticles and other complex 3D microstructures

Taylor, Matthew A.,

Behrens, Adam M.,

Jaklenec, Ana,

Nguyen, Thanh D.,

Norman, James J.,

Linehan, Allison R.,

Xu, Xian,

Langer, Robert,

Yang, David,

Guarecuco, Rohiverth,

Lu, Jennifer,

McHugh, Kevin J.,

Tomasic, Stephanie,

Tochka, Zachary L.,

Tzeng, Stephany Y.,

Rose, Sviatlana,

Anselmo, Aaron C.

2017

Overview

Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Biocompatibility

/ Biomedical materials